Ang(1-7) · MAS receptor agonist
Cardiovascular peptide — blood pressure, heart, and metabolic protection.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~1–2 hours
ROUTE
SubQ injection or intranasal
SCHEDULE
Daily
In Plain English
Cardiovascular peptide — blood pressure, heart, and metabolic protection.
Status & Legality
What do these mean?Cardiovascular protection
Blood pressure regulation
Metabolic health
Anti-fibrotic
Angiotensin 1-7 is an endogenous 7-amino acid peptide that counterbalances the vasoconstricting effects of Angiotensin II. Acting on the MAS receptor, it causes vasodilation, reduces fibrosis, improves insulin sensitivity, and has cardioprotective effects. It rises endogenously with ACE inhibitor use and represents a therapeutic target in cardiovascular disease.
Hypotension at high doses
Dizziness
Flushing
Generally well tolerated
Not monitoring blood pressure when starting — the vasodilatory effect can cause hypotension, especially if already on antihypertensive medications
Expecting it to replace cardiovascular medications — Ang 1-7 is a research compound for optimization; do not adjust prescriptions without physician guidance
Under-dosing below 100 mcg/day — effects are dose-dependent in the available research
ACE inhibitors — ACE inhibitors increase endogenous Ang 1-7 levels; combined use may cause hypotension
Antihypertensives — additive blood pressure lowering; monitor carefully
BPC-157 — generally synergistic for cardiovascular and systemic anti-inflammatory benefit
Angiotensin 1-7 represents the 'protective' arm of the renin-angiotensin system — the counterbalance to Angiotensin II's vasoconstrictive effects. For those with hypertension, metabolic syndrome, or cardiac risk factors, it offers a physiological cardioprotective mechanism. Monitor blood pressure when starting, especially if already on antihypertensives.
BPC-157
The top healing peptide — gut, tendons, joints.
CORTAGEN
Cardiovascular bioregulator — heart and blood vessel protection.
GONADORELIN
Native GnRH — testicular function and fertility on TRT.
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Stats
Sources & Studies
Ferreira AJ. et al., Curr Drug Targets, 2012