Creatine · Creatine Mono · Micronized Creatine
Muscle-preservation insurance during GLP-1–driven weight loss.
FDA
Approved
WADA
Not Listed
HALF-LIFE
~3h plasma; stored in muscle
ROUTE
Oral
SCHEDULE
Daily
In Plain English
Muscle-preservation insurance during GLP-1–driven weight loss.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
ApprovedFDA approved for human use.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Rx AvailableAvailable at licensed pharmacies with prescription.
PRESCRIBED
By prescriptionPhysicians can prescribe this compound legally.
ROUTE
OralAdministration via oral.
Muscle preservation
Strength & power output
ATP regeneration
GLP-1 adjunct
Creatine monohydrate is the most evidence-backed ergogenic supplement in existence with 1,000+ published studies. It increases phosphocreatine stores in muscle, accelerating ATP re-synthesis during high-intensity effort. In peptide protocols, it's most critical for GLP-1 users losing weight rapidly — creatine consistently reduces the muscle loss that accompanies caloric restriction, even without resistance training.
Intramuscular water retention (~1–2 kg)
GI discomfort at >10 g single doses
Mild DHT increase at high doses (evidence weak)
Generally excellent safety profile at 5 g/day
Buying HCl, ethyl ester, or 'buffered' forms — monohydrate is equal to or better than all other forms in every comparative study, at a fraction of the cost
Loading with 20 g/day when gradual 5 g/day reaches full muscle saturation equally — the loading phase just causes more water retention and GI discomfort
Not accounting for the 1–2 kg water weight increase when monitoring weight loss progress on GLP-1 protocols — this is intramuscular water, not body fat
Caffeine — historical concern about antagonism is not supported by modern evidence; safe to combine
Diuretics — may reduce creatine uptake by causing intramuscular dehydration; stay well hydrated
NSAIDs at very high doses combined with high creatine doses — theoretical renal concern; stay well hydrated
Creatine monohydrate is the most evidence-backed ergogenic supplement in existence with 1,000+ studies. On GLP-1 protocols, it's not optional — it's the most accessible countermeasure to the muscle loss that accompanies aggressive caloric restriction. 5 g/day, any time, any liquid. The loading phase is unnecessary for most users.
Stats
Sources & Studies
Buford TW. et al., J Int Soc Sports Nutr, 2007