Creatine · Creatine Mono · Micronized Creatine
Muscle-preservation insurance during GLP-1–driven weight loss.
FDA
Approved
WADA
Not Listed
HALF-LIFE
~3h plasma; stored in muscle
ROUTE
Oral
SCHEDULE
Daily
In Plain English
Muscle-preservation insurance during GLP-1–driven weight loss.
Status & Legality
What do these mean?Muscle preservation
Strength & power output
ATP regeneration
GLP-1 adjunct
Creatine monohydrate is the most evidence-backed ergogenic supplement in existence with 1,000+ published studies. It increases phosphocreatine stores in muscle, accelerating ATP re-synthesis during high-intensity effort. In peptide protocols, it's most critical for GLP-1 users losing weight rapidly — creatine consistently reduces the muscle loss that accompanies caloric restriction, even without resistance training.
Intramuscular water retention (~1–2 kg)
GI discomfort at >10 g single doses
Mild DHT increase at high doses (evidence weak)
Generally excellent safety profile at 5 g/day
Buying HCl, ethyl ester, or 'buffered' forms — monohydrate is equal to or better than all other forms in every comparative study, at a fraction of the cost
Loading with 20 g/day when gradual 5 g/day reaches full muscle saturation equally — the loading phase just causes more water retention and GI discomfort
Not accounting for the 1–2 kg water weight increase when monitoring weight loss progress on GLP-1 protocols — this is intramuscular water, not body fat
Caffeine — historical concern about antagonism is not supported by modern evidence; safe to combine
Diuretics — may reduce creatine uptake by causing intramuscular dehydration; stay well hydrated
NSAIDs at very high doses combined with high creatine doses — theoretical renal concern; stay well hydrated
Creatine monohydrate is the most evidence-backed ergogenic supplement in existence with 1,000+ studies. On GLP-1 protocols, it's not optional — it's the most accessible countermeasure to the muscle loss that accompanies aggressive caloric restriction. 5 g/day, any time, any liquid. The loading phase is unnecessary for most users.
SEMAGLUTIDE
FDA-approved GLP-1 agonist — weight loss and blood sugar control.
IGF-1 LR3
Long-acting IGF-1 — muscle growth and satellite cell activation.
VITAMIN D3 + K2
Baseline hormone-axis support that amplifies GH secretagogue outcomes.
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Stats
Sources & Studies
Buford TW. et al., J Int Soc Sports Nutr, 2007