Victoza · Saxenda
Daily GLP-1 agonist — the original injectable for weight loss.
FDA
Approved
WADA
Not Listed
HALF-LIFE
13 hours
ROUTE
SubQ injection (daily)
SCHEDULE
Daily
In Plain English
Daily GLP-1 agonist — the original injectable for weight loss.
Status & Legality
What do these mean?Weight loss
Type 2 diabetes
Cardiovascular protection
Liraglutide was the first GLP-1 agonist approved for chronic weight management (as Saxenda). While less potent than semaglutide for weight loss, it has a longer track record and is still widely used. It showed a 5–8% average body weight reduction in trials. Requires daily injection vs semaglutide's weekly.
Nausea
Diarrhea
Constipation
Headache
Injection site reaction
Rare: pancreatitis
Choosing liraglutide when semaglutide is available — weekly injection and meaningfully better weight loss make semaglutide the better choice for most
Not titrating properly — the weekly titration schedule is critical to tolerability
Missing daily injections — liraglutide's short half-life means missed doses matter significantly more than with once-weekly semaglutide
Insulin and sulfonylureas — hypoglycemia risk; reduce mealtime insulin when starting
Oral medications — slowed gastric emptying affects drug absorption; monitor levels for narrow therapeutic index drugs
Warfarin — monitor INR during active weight loss phases
Liraglutide works but is largely superseded by semaglutide in 2025+. The main reasons to choose it: shorter washout for pregnancy planning, specific insurance coverage, or established tolerance with an existing prescription. If starting fresh with no constraints, semaglutide is the better option for almost everyone.
GHK-CU
Anti-aging copper peptide — skin, hair, collagen, and wound repair.
SEMAGLUTIDE
FDA-approved GLP-1 agonist — weight loss and blood sugar control.
TIRZEPATIDE
Dual GIP/GLP-1 agonist — superior weight loss to semaglutide.
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Stats
Sources & Studies
Marso SP. et al., N Engl J Med, 2016