Palmitoyl Pentapeptide-4 · pal-KTTKS · Palmitoyl Tripeptide-1
Collagen-stimulating cosmeceutical — proven skin renewal.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
N/A (topical)
ROUTE
Topical
SCHEDULE
Daily
In Plain English
Collagen-stimulating cosmeceutical — proven skin renewal.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
TopicalAdministration via topical.
Collagen synthesis
Skin firmness
Wrinkle reduction
Anti-aging
Matrixyl 3000 is a combination of two palmitoylated peptides (pal-KTTKS and pal-GHK) that stimulate the synthesis of collagen, fibronectin, and hyaluronic acid. One of the most clinically validated cosmeceutical peptides with multiple double-blind trials confirming wrinkle reduction equivalent to low-concentration retinol.
Very well tolerated
Rare skin sensitivity
Using at less than 5% concentration — lower concentrations show limited collagen stimulation in clinical studies
Expecting it to replace retinol — Matrixyl stimulates collagen synthesis but doesn't increase cellular turnover like retinoids; they're complementary, not substitutes
Applying and rinsing off quickly — it requires time on skin to signal fibroblasts to produce collagen
Retinol/retinoids — safe to use at separate times (AM Matrixyl, PM retinol); complementary mechanisms for overall skin renewal
Vitamin C — safe to combine; both support collagen synthesis via different mechanisms
Hyaluronic acid — commonly combined; no interaction; hyaluronic acid provides the hydration matrix collagen builds into
Matrixyl 3000 is the most clinically validated collagen-stimulating cosmeceutical after retinol. Double-blind trials showing wrinkle reduction comparable to low-dose retinol make it among the best-evidenced topical peptides in the skincare market. Use in the morning at 5%; reserve retinol for evenings. Results are measurable at 3–6 months of consistent use.
Stats
Sources & Studies
Robinson LR. et al., Int J Cosmet Sci, 2005