Acetyl Octapeptide-3 · Leuphasyl
8-peptide expression-line reducer — stronger than Argireline.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
N/A (topical)
ROUTE
Topical
SCHEDULE
Daily
In Plain English
8-peptide expression-line reducer — stronger than Argireline.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
TopicalAdministration via topical.
Expression line reduction
Anti-aging
Facial muscle relaxation
SNAP-8 is an 8-amino acid peptide that extends the mechanism of Argireline by also inhibiting enkephalin release, providing dual inhibition of the acetylcholine-driven muscle contraction cascade. Clinical data shows up to 63% reduction in the depth of expression lines with 4% formulation.
Rare topical irritation
Very well tolerated
Using concentrations below 4% — clinical data showing 63% expression line depth reduction used 4% formulations; lower concentrations produce marginal results
Not pairing with Argireline — the dual pathway inhibition is meaningfully better than either compound alone
Expecting results without consistent twice-daily application for at least 4 weeks
Argireline — synergistic; combine in the same serum for the dual-pathway muscle relaxation effect
Injectable Botox — safe topical adjunct; may extend the duration of Botox results around injection sites
Vitamin C — layer after Vitamin C has been absorbed; apply Vitamin C first
SNAP-8 and Argireline together form the strongest over-the-counter expression-line treatment available. The dual-pathway inhibition addresses both catecholamine and enkephalin release in the neuromuscular junction — meaningfully more effective than Argireline alone. 4% concentration twice daily for 4+ weeks is the minimum protocol to see clinical results.
Stats
Sources & Studies
Neuropeptides as active ingredients in anti-aging cosmeceuticals
Gorouhi F, Maibach HI., Int J Cosmet Sci, 2009