Acetyl Octapeptide-3 · Leuphasyl
8-peptide expression-line reducer — stronger than Argireline.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
N/A (topical)
ROUTE
Topical
SCHEDULE
Daily
In Plain English
8-peptide expression-line reducer — stronger than Argireline.
Status & Legality
What do these mean?Expression line reduction
Anti-aging
Facial muscle relaxation
SNAP-8 is an 8-amino acid peptide that extends the mechanism of Argireline by also inhibiting enkephalin release, providing dual inhibition of the acetylcholine-driven muscle contraction cascade. Clinical data shows up to 63% reduction in the depth of expression lines with 4% formulation.
Rare topical irritation
Very well tolerated
Using concentrations below 4% — clinical data showing 63% expression line depth reduction used 4% formulations; lower concentrations produce marginal results
Not pairing with Argireline — the dual pathway inhibition is meaningfully better than either compound alone
Expecting results without consistent twice-daily application for at least 4 weeks
Argireline — synergistic; combine in the same serum for the dual-pathway muscle relaxation effect
Injectable Botox — safe topical adjunct; may extend the duration of Botox results around injection sites
Vitamin C — layer after Vitamin C has been absorbed; apply Vitamin C first
SNAP-8 and Argireline together form the strongest over-the-counter expression-line treatment available. The dual-pathway inhibition addresses both catecholamine and enkephalin release in the neuromuscular junction — meaningfully more effective than Argireline alone. 4% concentration twice daily for 4+ weeks is the minimum protocol to see clinical results.
ARGIRELINE
Topical botox-like peptide — reduces expression lines.
GHK-CU
Anti-aging copper peptide — skin, hair, collagen, and wound repair.
AHK-CU
Hair growth copper peptide — stimulates follicle proliferation.
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Stats
Sources & Studies
Neuropeptides as active ingredients in anti-aging cosmeceuticals
Gorouhi F, Maibach HI., Int J Cosmet Sci, 2009