Tauroursodeoxycholic Acid · Taurine Conjugate of UDCA · Ursodiol analog
Liver and bile-flow support when stacking peptides with oral or hepatotoxic compounds.
FDA
Approved
WADA
Not Listed
HALF-LIFE
~6–10 hours
ROUTE
Oral
SCHEDULE
Daily with food
In Plain English
Liver and bile-flow support when stacking peptides with oral or hepatotoxic compounds.
Status & Legality
What do these mean?Liver protection
Bile acid support
ER stress reduction
Hepatotoxic protocol adjunct
TUDCA (tauroursodeoxycholic acid) is an endogenous bile acid that protects hepatocytes from bile acid–induced apoptosis and reduces endoplasmic reticulum stress. It's the taurine-conjugated form of UDCA (ursodiol), which is FDA-approved for primary biliary cholangitis. In supplement contexts it's used as a hepatoprotective agent during protocols involving oral compounds or anything with liver burden.
Loose stool/diarrhea at high doses
Rare: nausea
Drug interactions with cholesterol-lowering medications
Generally excellent safety profile at 250–1000 mg/day
Taking without dietary fat — TUDCA is a bile acid; absorption improves significantly with fat in the stomach
Not getting baseline liver enzymes (ALT, AST) before starting intensive peptide protocols
Stopping immediately when a protocol ends — continue for 4 weeks post-protocol to clear residual hepatic stress
Cholesterol medications (statins, bile acid sequestrants) — TUDCA may affect bile acid metabolism; monitor lipids
Oral medications — bile acid changes can affect drug absorption; take TUDCA at a different meal time from other medications
Cyclosporine — TUDCA may alter blood levels; requires monitoring if on immunosuppression
TUDCA is the best liver protection supplement we have — the closely related FDA-approved drug ursodiol is used clinically for primary biliary cholangitis, confirming the hepatoprotective mechanism. For peptide users running oral compounds or anyone with hepatic concerns, 500 mg with a fat-containing meal is inexpensive protection. Always pair with NAC for dual-mechanism coverage.
NAC
Glutathione precursor and liver shield for heavy peptide protocols.
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Stats
Sources & Studies
Ozcan U. et al., Science, 2006