Index/GLP-2

GLP-2

Glucagon-Like Peptide-2 · Teduglutide · Gattex

Intestinal growth peptide — short bowel syndrome and gut repair.

FDA

Approved

WADA

Not Listed

HALF-LIFE

~7 hours (native), ~2 days (Teduglutide)

ROUTE

SubQ injection

SCHEDULE

Daily

In Plain English

Intestinal growth peptide — short bowel syndrome and gut repair.

Status & Legality

What do these mean?

NATTY?

No Test Exists

No established test exists for this compound.

FDA

Approved

FDA approved for human use.

WADA

Not Listed

Not currently on WADA prohibited list.

COMPOUNDING

Rx Available

Available at licensed pharmacies with prescription.

PRESCRIBED

By prescription

Physicians can prescribe this compound legally.

ROUTE

SubQ injection

Administration via subq injection.

Who It's For

Short bowel syndrome

Gut mucosal repair

Crohn's disease

Intestinal absorption

How It Works

GLP-2 is an intestinal growth factor produced by L-cells in the gut that promotes intestinal epithelial cell proliferation and reduces apoptosis. Teduglutide (Gattex) is the FDA-approved modified analog with a longer half-life. It's used medically for short bowel syndrome and has research applications in gut repair protocols.

Side Effects

Abdominal pain

Nausea

Fluid retention

Injection site reactions

Rare: intestinal obstruction

Common Mistakes

•

Using native GLP-2 when Teduglutide (the longer half-life analog) is available and appropriate

•

Not dose-adjusting by body weight — GLP-2 is one of the few research peptides with weight-based dosing protocols

•

Expecting gut results without adequate nutrition — intestinal epithelial repair requires sufficient dietary protein and micronutrients

Drug & Supplement Interactions

BPC-157 — synergistic gut repair combination; generally beneficial

Corticosteroids — may reduce the mucosal growth signaling that GLP-2 drives

Octreotide — can reduce endogenous GLP-2 activity when co-administered; avoid combination

The PepVault Take

GLP-2 is a gut repair peptide that works at the cellular proliferation level — stimulating intestinal villus growth and mucosal restoration. Most valuable for serious conditions like SBS or post-surgical gut rehabilitation. For general gut health, BPC-157 and KPV are more accessible and nearly as effective for most users.