Lys-Pro-Val · α-MSH tripeptide
Anti-inflammatory gut peptide — IBD, skin, wound healing.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–4 hours
ROUTE
Oral, topical, or SubQ injection
SCHEDULE
1–3× daily
In Plain English
Anti-inflammatory gut peptide — IBD, skin, wound healing.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
Oral, topical, or SubQ injectionAdministration via oral, topical, or subq injection.
IBD / gut inflammation
Wound healing
Skin conditions
Anti-inflammatory
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-MSH. It has potent anti-inflammatory effects by directly inhibiting NF-κB pathways in gut epithelial cells. Research shows strong promise for inflammatory bowel disease, Crohn's, and skin inflammation.
Generally very well tolerated
Mild skin darkening (topical)
Rare: injection site reaction
Using SubQ when gut is the target — oral is preferred for IBD applications due to direct mucosal contact
Dosing too infrequently for active inflammation — 2–3× daily is required for consistent anti-inflammatory effect
Expecting rapid results — KPV works over weeks, not days, for gut inflammation resolution
NSAIDs — additive anti-inflammatory effect; generally beneficial in gut protocols
Corticosteroids — may allow dose reduction over time; monitor with physician
No known significant adverse drug interactions
KPV is one of the most underrated gut peptides — particularly for IBD and Crohn's. The oral route has surprisingly good bioavailability for gut conditions; use SubQ only when systemic effects are the target. Best results come from pairing it with BPC-157 for a two-pronged anti-inflammatory + repair approach.
Stats
Sources & Studies
Brzoska T. et al., Endocr Rev, 2008