Lys-Pro-Val · α-MSH tripeptide
Anti-inflammatory gut peptide — IBD, skin, wound healing.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–4 hours
ROUTE
Oral, topical, or SubQ injection
SCHEDULE
1–3× daily
In Plain English
Anti-inflammatory gut peptide — IBD, skin, wound healing.
Status & Legality
What do these mean?IBD / gut inflammation
Wound healing
Skin conditions
Anti-inflammatory
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-MSH. It has potent anti-inflammatory effects by directly inhibiting NF-κB pathways in gut epithelial cells. Research shows strong promise for inflammatory bowel disease, Crohn's, and skin inflammation.
Generally very well tolerated
Mild skin darkening (topical)
Rare: injection site reaction
Using SubQ when gut is the target — oral is preferred for IBD applications due to direct mucosal contact
Dosing too infrequently for active inflammation — 2–3× daily is required for consistent anti-inflammatory effect
Expecting rapid results — KPV works over weeks, not days, for gut inflammation resolution
NSAIDs — additive anti-inflammatory effect; generally beneficial in gut protocols
Corticosteroids — may allow dose reduction over time; monitor with physician
No known significant adverse drug interactions
KPV is one of the most underrated gut peptides — particularly for IBD and Crohn's. The oral route has surprisingly good bioavailability for gut conditions; use SubQ only when systemic effects are the target. Best results come from pairing it with BPC-157 for a two-pronged anti-inflammatory + repair approach.
BPC-157
The top healing peptide — gut, tendons, joints.
LL-37
Human antimicrobial peptide — infection, wound healing, immune modulation.
TB-500
Systemic recovery — muscles, blood vessels, inflammation.
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Stats
Sources & Studies
Brzoska T. et al., Endocr Rev, 2008