HN · HNG · S14G-HN
Mitochondria-derived peptide — neuroprotection and metabolic regulation.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
Unknown
ROUTE
SubQ injection or intranasal
SCHEDULE
Daily to 3× weekly
In Plain English
Mitochondria-derived peptide — neuroprotection and metabolic regulation.
Status & Legality
What do these mean?Neuroprotection
Alzheimer's prevention
Metabolic health
Mitochondrial function
Humanin is a small mitochondrial-derived peptide (21 amino acids) encoded in mitochondrial DNA. It declines with age and in Alzheimer's patients. Research shows it protects neurons from amyloid-beta toxicity, improves insulin sensitivity, reduces cardiovascular risk, and extends lifespan in model organisms.
Generally very well tolerated
Mild injection site reactions
Using standard Humanin when S14G-HNG is available — HNG is 1,000× more potent and should be the default choice
Expecting immediate cognitive effects — neuroprotective effects are cumulative and build over weeks of consistent use
Dosing daily when 3× weekly produces comparable results at lower cost
Metformin — may have additive insulin-sensitizing effects via complementary pathways; monitor glucose
Insulin — metabolic effects on glucose; monitor during combined use
No known adverse drug interactions in current literature
Humanin is one of the most exciting longevity peptides in emerging research — mitochondrial-derived peptides represent a frontier that's only now being understood. The S14G (HNG) variant is meaningfully more potent and should always be the form chosen when available. Stack with MOTS-c for a comprehensive mitochondrial anti-aging protocol.
MOTS-C
Mitochondrial peptide — insulin sensitivity and exercise mimetic.
EPITHALON
Telomere extension peptide — the longevity compound.
GHK-CU
Anti-aging copper peptide — skin, hair, collagen, and wound repair.
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Stats
Sources & Studies
Hashimoto Y. et al., Science, 2001