HN · HNG · S14G-HN
Mitochondria-derived peptide — neuroprotection and metabolic regulation.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
Unknown
ROUTE
SubQ injection or intranasal
SCHEDULE
Daily to 3× weekly
In Plain English
Mitochondria-derived peptide — neuroprotection and metabolic regulation.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
SubQ injection or intranasalAdministration via subq injection or intranasal.
Neuroprotection
Alzheimer's prevention
Metabolic health
Mitochondrial function
Humanin is a small mitochondrial-derived peptide (21 amino acids) encoded in mitochondrial DNA. It declines with age and in Alzheimer's patients. Research shows it protects neurons from amyloid-beta toxicity, improves insulin sensitivity, reduces cardiovascular risk, and extends lifespan in model organisms.
Generally very well tolerated
Mild injection site reactions
Using standard Humanin when S14G-HNG is available — HNG is 1,000× more potent and should be the default choice
Expecting immediate cognitive effects — neuroprotective effects are cumulative and build over weeks of consistent use
Dosing daily when 3× weekly produces comparable results at lower cost
Metformin — may have additive insulin-sensitizing effects via complementary pathways; monitor glucose
Insulin — metabolic effects on glucose; monitor during combined use
No known adverse drug interactions in current literature
Humanin is one of the most exciting longevity peptides in emerging research — mitochondrial-derived peptides represent a frontier that's only now being understood. The S14G (HNG) variant is meaningfully more potent and should always be the form chosen when available. Stack with MOTS-c for a comprehensive mitochondrial anti-aging protocol.
Stats
Sources & Studies
Hashimoto Y. et al., Science, 2001