Lupron · Eligard · GnRH Agonist
GnRH agonist — chemical castration therapy and endometriosis.
FDA
Approved
WADA
Banned
HALF-LIFE
~3 hours (SC), months (depot)
ROUTE
SubQ injection or depot IM
SCHEDULE
Daily (SC) or monthly (depot)
In Plain English
GnRH agonist — chemical castration therapy and endometriosis.
Status & Legality
What do these mean?Prostate cancer
Endometriosis
Uterine fibroids
Precocious puberty
Leuprolide is a GnRH agonist that, with chronic use, causes downregulation of GnRH receptors and profound suppression of testosterone/estrogen. FDA-approved for multiple hormone-sensitive conditions. In the research context, it's sometimes used for chemical testosterone suppression in gender-affirming protocols.
Hot flashes
Bone density loss with chronic use
Depression
Cognitive changes
Sexual dysfunction
Initial testosterone flare
Using for performance enhancement — Leuprolide chronically suppresses testosterone (the opposite of most performance goals); this is a medical compound, not a performance tool
Using depot forms without oncology or reproductive endocrinology supervision — monthly and quarterly depots cause profound, prolonged hormonal changes
Not managing the testosterone flare on first dose in prostate cancer treatment — this is a clinical safety consideration, not an incidental effect
Antidiabetic medications — androgen deprivation therapy worsens insulin resistance; requires metabolic monitoring
Bone-density medications (bisphosphonates) — often co-prescribed for long-term Leuprolide use to offset bone loss
QT-prolonging medications — Leuprolide can prolong the QT interval; additive risk with other QT-prolonging drugs
Leuprolide is a strictly medical compound appropriate for prostate cancer, endometriosis, precocious puberty, and supervised fertility protocols. There is no legitimate performance-enhancing application — it suppresses testosterone. Anyone considering it outside a formal medical context should be working with a physician, not a peptide vendor.
GONADORELIN
Native GnRH — testicular function and fertility on TRT.
TRIPTORELIN
GnRH agonist — PCT and hormone axis resetting.
OXYTOCIN
Bonding hormone — social behavior, trust, and pain modulation.
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Stats
Sources & Studies
Seidenfeld J. et al., J Natl Cancer Inst, 2000