Lupron · Eligard · GnRH Agonist
GnRH agonist — chemical castration therapy and endometriosis.
FDA
Approved
WADA
Banned
HALF-LIFE
~3 hours (SC), months (depot)
ROUTE
SubQ injection or depot IM
SCHEDULE
Daily (SC) or monthly (depot)
In Plain English
GnRH agonist — chemical castration therapy and endometriosis.
Status & Legality
NATTY?
Not NattyWADA banned substance. Tested athletes will fail.
FDA
ApprovedFDA approved for human use.
WADA
BannedOn WADA prohibited list. Use disqualifies in tested sports.
COMPOUNDING
Rx AvailableAvailable at licensed pharmacies with prescription.
PRESCRIBED
By prescriptionPhysicians can prescribe this compound legally.
ROUTE
SubQ injection or depot IMAdministration via subq injection or depot im.
Prostate cancer
Endometriosis
Uterine fibroids
Precocious puberty
Leuprolide is a GnRH agonist that, with chronic use, causes downregulation of GnRH receptors and profound suppression of testosterone/estrogen. FDA-approved for multiple hormone-sensitive conditions. In the research context, it's sometimes used for chemical testosterone suppression in gender-affirming protocols.
Hot flashes
Bone density loss with chronic use
Depression
Cognitive changes
Sexual dysfunction
Initial testosterone flare
Using for performance enhancement — Leuprolide chronically suppresses testosterone (the opposite of most performance goals); this is a medical compound, not a performance tool
Using depot forms without oncology or reproductive endocrinology supervision — monthly and quarterly depots cause profound, prolonged hormonal changes
Not managing the testosterone flare on first dose in prostate cancer treatment — this is a clinical safety consideration, not an incidental effect
Antidiabetic medications — androgen deprivation therapy worsens insulin resistance; requires metabolic monitoring
Bone-density medications (bisphosphonates) — often co-prescribed for long-term Leuprolide use to offset bone loss
QT-prolonging medications — Leuprolide can prolong the QT interval; additive risk with other QT-prolonging drugs
Leuprolide is a strictly medical compound appropriate for prostate cancer, endometriosis, precocious puberty, and supervised fertility protocols. There is no legitimate performance-enhancing application — it suppresses testosterone. Anyone considering it outside a formal medical context should be working with a physician, not a peptide vendor.
Stats
Sources & Studies
Seidenfeld J. et al., J Natl Cancer Inst, 2000