Decapeptyl · Trelstar · GnRH agonist
GnRH agonist — PCT and hormone axis resetting.
FDA
Approved
WADA
Banned
HALF-LIFE
~2.8 hours (short-acting), ~weeks (depot)
ROUTE
IM injection
SCHEDULE
Single dose (PCT) or monthly (depot)
In Plain English
GnRH agonist — PCT and hormone axis resetting.
Status & Legality
What do these mean?PCT after anabolic use
Prostate cancer
Precocious puberty
Endometriosis
Triptorelin is a potent GnRH agonist FDA-approved for prostate cancer and precocious puberty. In performance contexts, a single low dose is used for post-cycle therapy (PCT) to trigger a powerful LH surge and restart the HPG axis. It has largely replaced clomid/nolvadex in many advanced PCT protocols.
Temporary testosterone suppression after single dose before recovery
Hot flashes
GI upset
Depression (with chronic use)
Using the depot (monthly) form for PCT — the depot causes prolonged suppression of 3–6 months; only the short-acting form is appropriate for PCT
Timing it incorrectly — start Triptorelin PCT 2 weeks after the last long-ester anabolic compound clears; timing relative to clearance is critical
Not understanding the initial testosterone flare — the first dose triggers a significant LH surge and testosterone spike before the agonist effect kicks in
GnRH antagonists — counterproductive; do not combine
Long-ester testosterone — timing the last injection correctly before PCT is critical for proper clearance
Antiandrogens — sometimes used clinically with the first dose to manage the testosterone flare in prostate cancer; not typically needed in PCT use
Single-dose Triptorelin PCT (100–200 mcg short-acting) has replaced clomid/nolvadex protocols for many advanced users due to its reliable HPG axis restart via the initial LH surge. Critical point: only use the short-acting form. The depot version creates months of testosterone suppression — the exact opposite of what PCT requires.
GONADORELIN
Native GnRH — testicular function and fertility on TRT.
LEUPROLIDE
GnRH agonist — chemical castration therapy and endometriosis.
OXYTOCIN
Bonding hormone — social behavior, trust, and pain modulation.
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Stats
Sources & Studies
Triptorelin: a GnRH agonist for advanced prostate cancer and endometriosis
Crawford ED. et al., Expert Opin Pharmacother, 2009