Mechano Growth Factor · IGF-1Ec
Splice variant of IGF-1 — satellite cell activation for muscle repair.
FDA
Research Only
WADA
Banned
HALF-LIFE
Minutes (native), longer (PEGylated)
ROUTE
IM injection
SCHEDULE
Post-workout
In Plain English
Splice variant of IGF-1 — satellite cell activation for muscle repair.
Status & Legality
What do these mean?Satellite cell activation
Muscle repair
Post-workout recovery
Hypertrophy
Mechano Growth Factor is an isoform of IGF-1 (IGF-1Ec) expressed locally in muscle tissue in response to mechanical load. It activates quiescent satellite cells — the muscle stem cells — to repair and grow muscle fibers. It acts before IGF-1 LR3 in the muscle growth cascade.
Hypoglycemia (mild)
Injection site soreness
Headache
Injecting anywhere other than the trained muscle — localized satellite cell activation requires injection at the specific site of mechanical load
Not injecting immediately post-workout — the window for maximum MGF effectiveness is narrow; within 30 minutes of training is standard
Using MGF without following up with IGF-1 LR3 — MGF activates satellite cells but doesn't drive protein synthesis; LR3 completes the growth cascade
Insulin — mild hypoglycemia risk; have carbohydrates available post-injection
IGF-1 LR3 — sequential use (MGF first, LR3 30–60 min later) is the optimal protocol; complementary not competitive
GH secretagogues — generally safe; complementary anabolic signaling mechanisms
MGF is the satellite cell primer — it activates the muscle stem cells that respond to mechanical load. Use it immediately post-workout into the trained muscles, then follow with IGF-1 LR3 30–60 minutes later. This sequence artificially replicates the natural muscle growth signaling cascade more completely than either compound alone.
IGF-1 LR3
Long-acting IGF-1 — muscle growth and satellite cell activation.
TB-500
Systemic recovery — muscles, blood vessels, inflammation.
IGF-1 DES
Short-acting IGF-1 — localized muscle hypertrophy.
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Stats
Sources & Studies
Yang SY. et al., J Physiol, 2004