Thymosin Beta-4 · Tβ4
Systemic recovery — muscles, blood vessels, inflammation.
FDA
Reclassified '26
WADA
Banned
HALF-LIFE
~Days (estimated)
ROUTE
SubQ or IM injection
SCHEDULE
2× weekly
In Plain English
TB-500 works systemically — it travels through your entire body to reduce inflammation and repair tissue everywhere at once. Use it for widespread or hard-to-reach injuries where a local peptide alone isn't enough.
Status & Legality
NATTY?
Not NattyWADA banned substance. Tested athletes will fail.
FDA
Reclassified '26Compounding pharmacies may prepare under physician oversight.
WADA
BannedOn WADA prohibited list. Use disqualifies in tested sports.
COMPOUNDING
Category 1Compounding pharmacies may prepare post-2026 reclassification.
PRESCRIBED
Off-label compoundsNot prescribed in conventional medicine.
ROUTE
SubQ or IM injectionAdministration via subq or im injection.
People with multiple or widespread injuries
Athletes recovering from systemic inflammation
Anyone stacking with BPC-157 for comprehensive healing
Active or suspected malignancy (pro-angiogenic effects — unconfirmed risk in humans)
Pregnancy or nursing
Injection site infection
TB-500 is a synthetic version of Thymosin Beta-4, present in nearly all human and animal cells. Unlike BPC-157's localized action, TB-500 travels systemically — promoting cell migration, new blood vessel formation, and reducing chronic inflammation body-wide. It's the go-to peptide for widespread or multi-site injuries.
Fatigue during loading
Headaches
Nausea
Injection site irritation
Theoretical tumor promotion concern (not confirmed in humans)
Running TB-500 solo for localized injuries without adding BPC-157
Skipping off-cycle breaks — 6 weeks on, 2–4 weeks minimum off
Exceeding 5 mg doses without medical supervision
BPC-157 — synergistic combination, not a conflict
GH peptides — healing acceleration stacks well
No documented adverse drug interactions in current literature
TB-500 is most powerful as the systemic half of a BPC-157 stack. Running it solo for localized injuries is less efficient. The WADA ban makes this one to research carefully if you're a tested athlete.
Stats
Sources & Studies
Goldstein AL. et al., Expert Opin Biol Ther, 2012