Nicotinamide Mononucleotide · β-NMN · Beta-NMN
The most direct oral precursor to NAD+ — fast conversion, strong uptake.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–3 hours
ROUTE
Oral (sublingual or capsule)
SCHEDULE
Daily, morning
In Plain English
The most direct oral precursor to NAD+ — fast conversion, strong uptake.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
Oral (sublingual or capsule)Administration via oral (sublingual or capsule).
NAD+ elevation
Metabolic support
Longevity signaling
Mitochondrial biogenesis
NMN is a direct biosynthetic precursor to NAD+, rapidly converted in the gut and liver. It became a longevity staple after David Sinclair's research at Harvard demonstrated NAD+ decline as a key driver of aging. Human trials show meaningful NAD+ elevation within weeks. The FDA's attempt to classify NMN as a drug ingredient in 2022 created regulatory ambiguity, though it remains widely available as a supplement.
Mild nausea at high doses
Headache initially (resolves)
Flushing at very high doses (uncommon)
Generally very well tolerated
Storing at room temperature — NMN degrades with heat and moisture; refrigeration of open containers is required
Expecting measurable results in days — NAD+ tissue elevation takes 2–4 weeks of consistent supplementation to reach meaningful levels
Not pairing with a sirtuin activator — NMN raises the NAD+ substrate, but without resveratrol or pterostilbene activating sirtuins, the pathway runs below potential
Resveratrol and pterostilbene — classic longevity synergy; NMN raises NAD+, sirtuin activators harness it
Alcohol — rapidly depletes NAD+ stores via alcohol dehydrogenase; habitual alcohol use undermines NMN supplementation
Chemotherapy drugs — some protocols involve NAD+ depletion; consult oncologist before combining NMN with cancer treatment
Sublingual NMN at 500 mg is the most practical NAD+ strategy — bypasses much of the gut degradation. The Sinclair combination (NMN + resveratrol + CoQ10) remains the most replicated longevity supplement protocol. Always pair with a sirtuin activator — NMN alone raises NAD+ but the downstream longevity signaling requires the SIRT1 activation that resveratrol or pterostilbene provides.
Stats
Sources & Studies
Igarashi M. et al., npj Aging, 2022