Nicotinamide Mononucleotide · β-NMN · Beta-NMN
The most direct oral precursor to NAD+ — fast conversion, strong uptake.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–3 hours
ROUTE
Oral (sublingual or capsule)
SCHEDULE
Daily, morning
In Plain English
The most direct oral precursor to NAD+ — fast conversion, strong uptake.
Status & Legality
What do these mean?NAD+ elevation
Metabolic support
Longevity signaling
Mitochondrial biogenesis
NMN is a direct biosynthetic precursor to NAD+, rapidly converted in the gut and liver. It became a longevity staple after David Sinclair's research at Harvard demonstrated NAD+ decline as a key driver of aging. Human trials show meaningful NAD+ elevation within weeks. The FDA's attempt to classify NMN as a drug ingredient in 2022 created regulatory ambiguity, though it remains widely available as a supplement.
Mild nausea at high doses
Headache initially (resolves)
Flushing at very high doses (uncommon)
Generally very well tolerated
Storing at room temperature — NMN degrades with heat and moisture; refrigeration of open containers is required
Expecting measurable results in days — NAD+ tissue elevation takes 2–4 weeks of consistent supplementation to reach meaningful levels
Not pairing with a sirtuin activator — NMN raises the NAD+ substrate, but without resveratrol or pterostilbene activating sirtuins, the pathway runs below potential
Resveratrol and pterostilbene — classic longevity synergy; NMN raises NAD+, sirtuin activators harness it
Alcohol — rapidly depletes NAD+ stores via alcohol dehydrogenase; habitual alcohol use undermines NMN supplementation
Chemotherapy drugs — some protocols involve NAD+ depletion; consult oncologist before combining NMN with cancer treatment
Sublingual NMN at 500 mg is the most practical NAD+ strategy — bypasses much of the gut degradation. The Sinclair combination (NMN + resveratrol + CoQ10) remains the most replicated longevity supplement protocol. Always pair with a sirtuin activator — NMN alone raises NAD+ but the downstream longevity signaling requires the SIRT1 activation that resveratrol or pterostilbene provides.
RESVERATROL
The sirtuin activator from red wine — synergizes with NAD+ for longevity signaling.
EPITHALON
Telomere extension peptide — the longevity compound.
PTEROSTILBENE
More bioavailable resveratrol analogue with better half-life and CNS penetration.
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Stats
Sources & Studies
Igarashi M. et al., npj Aging, 2022