Anti-Obesity Drug · Tyr-hGH(177-191)
HGH fragment for targeted fat burning — no anabolic effects.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~30 minutes
ROUTE
SubQ injection or oral
SCHEDULE
Daily
In Plain English
HGH fragment for targeted fat burning — no anabolic effects.
Status & Legality
What do these mean?Fat loss
Lipolysis
Metabolism
Cartilage repair
AOD-9604 is a modified fragment of human growth hormone (amino acids 177–191) that retains the lipolytic (fat-burning) properties of HGH without anabolic or blood sugar effects. It stimulates fat cell breakdown and inhibits lipogenesis. Gained TGA approval in Australia as a food ingredient.
Generally very well tolerated
Injection site irritation
Mild hypoglycemia (very rare)
Headache (uncommon)
Expecting dramatic fat loss without caloric control — AOD-9604 enhances lipolysis but does not override dietary excess
Not injecting fasted — eating before the injection blunts the lipolytic response significantly
Comparing results to GLP-1 agonists — AOD-9604 has modest, targeted effects; GLP-1s are more potent for total weight loss
GLP-1 agonists (semaglutide) — can be combined for dual fat loss mechanisms; different pathways
Insulin — monitor glucose during fasted injections, though hypoglycemia risk is very low with this compound
GH secretagogues — generally synergistic; commonly combined in fat loss protocols
AOD-9604 is a clean, targeted fat-burning peptide — none of the anabolic or glucose effects of full HGH, just the lipolytic fragment. Results are real but subtle compared to GLP-1s. Best used as an adjunct during body recomposition rather than a primary weight loss tool. Fasted AM injection is non-negotiable.
CJC-1295 (NO DAC)
Short-acting GHRH analog — clean GH pulses.
SEMAGLUTIDE
FDA-approved GLP-1 agonist — weight loss and blood sugar control.
HGH FRAGMENT 176-191
Lipolytic GH fragment — pure fat burning without growth effects.
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Stats
Sources & Studies
Heffernan M. et al., Endocrine, 2001