MOD-GRF(1-29) · Modified GRF 1-29
Short-acting GHRH analog — clean GH pulses.
FDA
Reclassified '26
WADA
Banned
HALF-LIFE
30 minutes
ROUTE
SubQ injection
SCHEDULE
1–3× daily
In Plain English
Short-acting GHRH analog — clean GH pulses.
Status & Legality
NATTY?
Not NattyWADA banned substance. Tested athletes will fail.
FDA
Reclassified '26Compounding pharmacies may prepare under physician oversight.
WADA
BannedOn WADA prohibited list. Use disqualifies in tested sports.
COMPOUNDING
Category 1Compounding pharmacies may prepare post-2026 reclassification.
PRESCRIBED
Off-label compoundsNot prescribed in conventional medicine.
ROUTE
SubQ injectionAdministration via subq injection.
GH stimulation
Anti-aging
Fat loss
Recovery
CJC-1295 without DAC (also called MOD-GRF 1-29) is a modified GHRH analog with a 30-minute half-life, producing sharp, pulsatile GH release that closely mimics the body's natural rhythms. Unlike the DAC version, it must be injected multiple times per day but is preferred by those wanting more physiological GH pulses.
Water retention
Tingling/numbness
Fatigue
Hunger increase
Injection site irritation
Eating within 30 minutes of injection — food, especially carbohydrates, significantly blunts the GH response
Not pairing with a GHRP — CJC alone produces a fraction of the GH release compared to the GHRH + GHRP combination
Expecting muscle gain without training — GH peptides amplify training response; they don't produce results in sedentary individuals
Insulin and diabetes medications — GH elevation reduces insulin sensitivity; monitor glucose during long cycles
Glucocorticoids — blunt the pituitary GH response; avoid combining
Thyroid medications — adequate thyroid function affects GH axis responsiveness; optimize thyroid before starting
200 mcg CJC no-DAC + 200 mcg Ipamorelin before sleep is the gold standard starter GH protocol. Always inject fasted — even a small meal significantly blunts the GH pulse. The pre-sleep timing aligns with the body's natural GH surge during slow-wave sleep for maximum effect.
Stats
Sources & Studies
Teichman SL. et al., J Clin Endocrinol Metab, 2006