HGH Frag · Fragment 176-191
Lipolytic GH fragment — pure fat burning without growth effects.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~30 minutes
ROUTE
SubQ injection
SCHEDULE
Daily
In Plain English
Lipolytic GH fragment — pure fat burning without growth effects.
Status & Legality
What do these mean?Fat loss
Lipolysis
Stubborn fat reduction
HGH Fragment 176-191 is the C-terminal end of human growth hormone, specifically isolated for its fat-burning properties. Unlike full HGH, it doesn't raise IGF-1 or affect blood glucose, making it safer for metabolic use. It works by regulating fat metabolism through a mechanism distinct from the GH receptor.
Injection site redness
Drowsiness (rare)
Well tolerated overall
Expecting the anabolic or IGF-1-raising effects of full HGH — this fragment specifically lacks those effects; it's purely lipolytic
Not splitting the dose — the very short half-life means a single daily dose covers a narrow window; split AM + pre-workout
Eating within 30 minutes of injection — the fasting requirement for the lipolytic effect is strict
Insulin — fasted injection means blood glucose should be available; hypoglycemia is rare but possible at high doses
GH secretagogues (CJC/Ipamorelin) — commonly combined; generally safe and synergistic for fat loss
Semaglutide — different mechanisms; can be combined in a comprehensive fat loss protocol
HGH Frag is the 'safe' version of HGH fat burning — no IGF-1 elevation, no glucose effects, just the lipolytic mechanism. Results are meaningful but modest. Best used as part of a broader protocol that includes caloric control and GH secretagogues at night for sleep and recovery benefits.
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Stats
Sources & Studies
Ng FM. et al., Mol Cell Endocrinol, 1990