CJC-1295 · DAC:GRF
Long-acting GHRH analog — once or twice weekly dosing.
FDA
Reclassified '26
WADA
Banned
HALF-LIFE
6–8 days
ROUTE
SubQ injection
SCHEDULE
1–2× weekly
In Plain English
Long-acting GHRH analog — once or twice weekly dosing.
Status & Legality
What do these mean?GH stimulation
Anti-aging
Muscle recovery
CJC-1295 with DAC (Drug Affinity Complex) extends the half-life to 6–8 days by binding to albumin. This creates a sustained GH release (the 'bleed') rather than sharp pulses. Ideal for those wanting convenience — once or twice weekly injections. The trade-off is less physiological pulse rhythm.
Water retention (more than no-DAC version)
Tingling
Fatigue
Hunger
Potential desensitization with long-term continuous use
Using without a GHRP — the sustained bleed without pulsatile release is significantly less effective than the combination
Dosing more than twice weekly — once or twice weekly is sufficient; more frequent dosing creates desensitization without added benefit
Expecting immediate results — sustained GH elevation from DAC takes 2–4 weeks to show measurable effects on body composition
Insulin — GH elevation reduces insulin sensitivity; monitor glucose during extended cycles
Somatostatin analogs (octreotide) — block GH release; do not combine
Thyroid hormones — thyroid optimization before GH axis protocols improves the overall response
CJC-DAC's convenience (1–2 injections/week) is its main selling point. The trade-off is less physiological GH pulsing compared to no-DAC. If you want the cleanest, most natural pulse rhythm, use no-DAC + Ipamorelin. If compliance and convenience matter more than optimization, DAC is a reasonable choice.
IPAMORELIN
Cleanest GH secretagogue — minimal cortisol, strong pulse.
CJC-1295 (NO DAC)
Short-acting GHRH analog — clean GH pulses.
GHRP-2
Potent GH secretagogue — strong pulses with appetite stimulation.
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Stats
Sources & Studies
Teichman SL. et al., J Clin Endocrinol Metab, 2006