NNC 26-0161
Cleanest GH secretagogue — minimal cortisol, strong pulse.
FDA
Reclassified '26
WADA
Banned
HALF-LIFE
~2 hours
ROUTE
SubQ injection
SCHEDULE
1–3× daily
In Plain English
Cleanest GH secretagogue — minimal cortisol, strong pulse.
Status & Legality
What do these mean?GH release
Anti-aging
Sleep quality
Recovery
Ipamorelin is a selective growth hormone secretagogue that stimulates the pituitary to release GH with minimal side effects. Unlike GHRP-2 and GHRP-6, it produces negligible cortisol and prolactin elevation, making it the most tolerable GHRP. It's the preferred starting GHRP for most users.
Mild headache
Flushing
Tingling/numbness
Water retention (minimal)
Injecting within 2 hours of eating — food blunts the GH response significantly; fasted injection is non-negotiable
Not pairing with a GHRH — Ipamorelin + CJC is 2–5× more potent than either compound alone
Using it without exercising expecting body composition changes — GH peptides amplify recovery and fat loss; training is required for meaningful results
Insulin and diabetes medications — modest GH elevation can reduce insulin sensitivity; monitor glucose
Corticosteroids — directly blunt the pituitary GH response
SSRIs — may modestly reduce somatotroph responsiveness at high doses
Ipamorelin is the cleanest GHRP available — minimal cortisol and prolactin elevation compared to GHRP-2 or GHRP-6. For most users, 200 mcg Ipamorelin + 200 mcg CJC-1295 (no DAC) injected together before sleep is the ideal starting protocol. Sleep quality improvements are typically noticed first; body composition changes follow at weeks 6–8.
CJC-1295 (NO DAC)
Short-acting GHRH analog — clean GH pulses.
TB-500
Systemic recovery — muscles, blood vessels, inflammation.
CJC-1295 DAC
Long-acting GHRH analog — once or twice weekly dosing.
Free, no account needed
Drop your email and we'll send the one-page starter checklist beginners actually need first. No account needed.
No spam, and we never sell your email. Just the checklist. Email support@pepvault.us to opt out any time.
Stats
Sources & Studies
Raun K. et al., Eur J Endocrinol, 1998