PNB-0408 · HGF activator
7× more potent than BDNF — the strongest nootropic peptide.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–4 hours
ROUTE
Oral or transdermal
SCHEDULE
As needed (not daily)
In Plain English
7× more potent than BDNF — the strongest nootropic peptide.
Status & Legality
What do these mean?Memory enhancement
Cognitive decline
Alzheimer's prevention
Neuroplasticity
Dihexa (PNB-0408) is an angiotensin-derived nootropic that potentiates hepatocyte growth factor (HGF) signaling and is reportedly 7× more potent than BDNF in improving cognitive performance in animal models. Users report significant memory enhancement and improved learning. Its high potency means low doses and infrequent use.
Unknown long-term safety profile
Potential mood changes
Overstimulation at high doses
Dosing daily — Dihexa's potency means daily use leads to overstimulation and rapid tolerance; 1–2×/week is the recommended frequency
Exceeding 30 mg per dose — no additional cognitive benefit; only more side effect risk
Overlooking the thin safety data — Dihexa is among the least-studied nootropics in the index; conservative use and cycling are warranted
Other nootropics — additive effects can be unpredictable; introduce each compound separately before combining
Stimulants — may cause significant overstimulation
Anticoagulants — HGF signaling may influence platelet function; monitor if on blood thinners
Dihexa is the most potent nootropic peptide available but also the most research-sparse. Start at 5–10 mg once weekly and assess your response carefully. The memory enhancement is distinctive but the long-term safety profile is essentially unknown — use sparingly and cyclically, not as a daily supplement.
SEMAX
Neuroprotective ACTH analog — focus, memory, and BDNF.
SELANK
Anti-anxiety nootropic — calm focus without sedation.
P21
CNTF-derived nootropic — neurogenesis and cognitive restoration.
Free, no account needed
Drop your email and we'll send the one-page starter checklist beginners actually need first. No account needed.
No spam, and we never sell your email. Just the checklist. Email support@pepvault.us to opt out any time.
Stats
Sources & Studies
Benoist CC. et al., J Pharmacol Exp Ther, 2011