PNB-0408 · HGF activator
7× more potent than BDNF — the strongest nootropic peptide.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~2–4 hours
ROUTE
Oral or transdermal
SCHEDULE
As needed (not daily)
In Plain English
7× more potent than BDNF — the strongest nootropic peptide.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
Oral or transdermalAdministration via oral or transdermal.
Memory enhancement
Cognitive decline
Alzheimer's prevention
Neuroplasticity
Dihexa (PNB-0408) is an angiotensin-derived nootropic that potentiates hepatocyte growth factor (HGF) signaling and is reportedly 7× more potent than BDNF in improving cognitive performance in animal models. Users report significant memory enhancement and improved learning. Its high potency means low doses and infrequent use.
Unknown long-term safety profile
Potential mood changes
Overstimulation at high doses
Dosing daily — Dihexa's potency means daily use leads to overstimulation and rapid tolerance; 1–2×/week is the recommended frequency
Exceeding 30 mg per dose — no additional cognitive benefit; only more side effect risk
Overlooking the thin safety data — Dihexa is among the least-studied nootropics in the index; conservative use and cycling are warranted
Other nootropics — additive effects can be unpredictable; introduce each compound separately before combining
Stimulants — may cause significant overstimulation
Anticoagulants — HGF signaling may influence platelet function; monitor if on blood thinners
Dihexa is the most potent nootropic peptide available but also the most research-sparse. Start at 5–10 mg once weekly and assess your response carefully. The memory enhancement is distinctive but the long-term safety profile is essentially unknown — use sparingly and cyclically, not as a daily supplement.
Stats
Sources & Studies
Benoist CC. et al., J Pharmacol Exp Ther, 2011