TP-7 · Tuftsin analog
Anti-anxiety nootropic — calm focus without sedation.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
Minutes (intranasal), effects last hours
ROUTE
Intranasal spray
SCHEDULE
As needed or 1–3× daily
In Plain English
Anti-anxiety nootropic — calm focus without sedation.
Status & Legality
What do these mean?Anxiety reduction
Cognitive enhancement
BDNF elevation
Mood stabilization
Selank is a synthetic analog of Tuftsin developed by the Institute of Molecular Genetics in Russia. It modulates GABA receptor activity, elevates BDNF, and reduces anxiety without the dependency or sedation risks of benzodiazepines. Users report a sense of calm focus with improved working memory.
Mild nasal irritation
Drowsiness (some users)
Headache (rare)
Very low side effect profile
Using it expecting sedation — Selank is anxiolytic without sedation; persistent drowsiness suggests the dose is too high
Not using consistently for anxiety — works best with regular daily use over weeks; as-needed use produces weaker results
Storing without refrigeration — intranasal peptide solutions degrade quickly at room temperature; always refrigerate
Benzodiazepines — may have additive anxiolytic effects; reduce benzo dose before combining to avoid excessive CNS depression
SSRIs and SNRIs — generally safe to combine; some users report enhanced mood with the combination
Alcohol — avoid; can potentiate CNS effects unpredictably
Selank is the most underrated anxiolytic available — no dependency, no sedation, no tolerance buildup. The calm, alert focus it produces is distinctive compared to any conventional anxiolytic. For daily anxiety management, 250–500 mcg per nostril 1–2× daily is the sweet spot. Pair with Semax for a comprehensive cognitive + anxiolytic protocol.
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EPITHALON
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DIHEXA
7× more potent than BDNF — the strongest nootropic peptide.
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Stats
Sources & Studies
Zozulya AA. et al., Peptides, 2001