3,3',4',7-tetrahydroxyflavone · Smoke tree extract
The most potent natural senolytic — selectively clears zombie cells that drive aging.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~3–5 hours
ROUTE
Oral
SCHEDULE
Pulsed monthly protocol
In Plain English
The most potent natural senolytic — selectively clears zombie cells that drive aging.
Status & Legality
What do these mean?Senescent cell clearance
Neuroinflammation reduction
Longevity signaling
Anti-inflammatory
Fisetin is a flavonoid found in strawberries that is considered the most potent natural senolytic identified to date — more effective than quercetin in preclinical models. It clears senescent cells (zombie cells that secrete SASP inflammatory signals) by inhibiting BCL-2/BCL-XL survival pathways. A 2018 EBioMedicine study found fisetin extended median lifespan in mice by 10%. Currently in human clinical trials. Unlike daily supplements, fisetin is most effective in pulsed high-dose cycles.
GI discomfort at high doses
Mild fatigue during pulsed days
Headache occasionally
Generally very well tolerated — among the best-tolerated senolytics
Daily continuous use at low doses — continuous daily fisetin doesn't achieve the senolytic clearance that pulsed high-dose monthly cycles produce
Not taking with fat — fisetin is fat-soluble; absorption without a fat-containing meal or added fat is very poor
Expecting visible physical changes within weeks — senolytic effects on inflammation and cellular aging accumulate over months of consistent monthly cycling
Anticoagulants (warfarin) — mild blood-thinning effect at high pulsed doses; monitor INR
Immunosuppressants — fisetin has immune-modulating effects that may interact with immunosuppressive drugs
BCL-2-targeting cancer drugs — fisetin inhibits BCL-2 survival proteins; potential interaction with dasatinib and similar; discuss with oncologist
Fisetin has the best animal longevity data of any natural compound — 10%+ lifespan extension in mice with the pulsed dosing protocol. The monthly pulsed approach (500 mg/day for 2–3 consecutive days) is how you get the senolytic effect, not daily supplementation. Always take with a high-fat meal; without fat, absorption is minimal and the dose is largely wasted.
QUERCETIN
Dual-action polyphenol and senolytic — clears aged cells while reducing inflammation.
EPITHALON
Telomere extension peptide — the longevity compound.
SPERMIDINE
Triggers autophagy — the cellular cleanup process that declines with age.
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Stats
Sources & Studies
Yousefzadeh MJ. et al., EBioMedicine, 2018