3,3',4',7-tetrahydroxyflavone · Smoke tree extract
The most potent natural senolytic — selectively clears zombie cells that drive aging.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~3–5 hours
ROUTE
Oral
SCHEDULE
Pulsed monthly protocol
In Plain English
The most potent natural senolytic — selectively clears zombie cells that drive aging.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
OralAdministration via oral.
Senescent cell clearance
Neuroinflammation reduction
Longevity signaling
Anti-inflammatory
Fisetin is a flavonoid found in strawberries that is considered the most potent natural senolytic identified to date — more effective than quercetin in preclinical models. It clears senescent cells (zombie cells that secrete SASP inflammatory signals) by inhibiting BCL-2/BCL-XL survival pathways. A 2018 EBioMedicine study found fisetin extended median lifespan in mice by 10%. Currently in human clinical trials. Unlike daily supplements, fisetin is most effective in pulsed high-dose cycles.
GI discomfort at high doses
Mild fatigue during pulsed days
Headache occasionally
Generally very well tolerated — among the best-tolerated senolytics
Daily continuous use at low doses — continuous daily fisetin doesn't achieve the senolytic clearance that pulsed high-dose monthly cycles produce
Not taking with fat — fisetin is fat-soluble; absorption without a fat-containing meal or added fat is very poor
Expecting visible physical changes within weeks — senolytic effects on inflammation and cellular aging accumulate over months of consistent monthly cycling
Anticoagulants (warfarin) — mild blood-thinning effect at high pulsed doses; monitor INR
Immunosuppressants — fisetin has immune-modulating effects that may interact with immunosuppressive drugs
BCL-2-targeting cancer drugs — fisetin inhibits BCL-2 survival proteins; potential interaction with dasatinib and similar; discuss with oncologist
Fisetin has the best animal longevity data of any natural compound — 10%+ lifespan extension in mice with the pulsed dosing protocol. The monthly pulsed approach (500 mg/day for 2–3 consecutive days) is how you get the senolytic effect, not daily supplementation. Always take with a high-fat meal; without fat, absorption is minimal and the dose is largely wasted.
Stats
Sources & Studies
Yousefzadeh MJ. et al., EBioMedicine, 2018