KP-10 · Metastin analog
Gonadotropin-releasing hormone trigger — libido and fertility.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~28 minutes
ROUTE
SubQ injection
SCHEDULE
As needed
In Plain English
Gonadotropin-releasing hormone trigger — libido and fertility.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
SubQ injectionAdministration via subq injection.
LH/FSH stimulation
Libido
Fertility
Hypogonadism
Kisspeptin-10 is the endogenous trigger for GnRH release from the hypothalamus, initiating the entire reproductive hormone cascade (GnRH → LH/FSH → testosterone/estrogen). It's the gatekeeper of puberty onset and reproductive function. Research shows acute kisspeptin administration restores sexual arousal and relationship bonding.
Flushing
Mild nausea
LH surge can cause temporary reproductive axis stimulation
Generally well tolerated
Not calculating doses by body weight — Kisspeptin is one of the few research peptides where nmol/kg dosing is the standard; bodyweight-independent dosing produces inconsistent results
Expecting it to substitute for testosterone — Kisspeptin stimulates the hormone cascade but cannot replace exogenous testosterone when deficiency is the root issue
Using it alongside GnRH suppressors — combining with leuprolide, buserelin, or other GnRH agonists in suppressive regimens is directly counterproductive
GnRH suppressors (leuprolide, buserelin) — directly antagonistic; do not combine
Opioids — suppress kisspeptin neurons in the hypothalamus; effectiveness is reduced with opioid co-administration
Testosterone — generally safe; kisspeptin drives endogenous production; may be used alongside TRT for HPG support
Kisspeptin is the natural master switch for the reproductive hormone axis. For men seeking to maximize natural testosterone or restore HPG function post-cycle, it offers a physiological approach that most compounds ignore. For fertility protocols, work with a reproductive endocrinologist — the timing and dosing protocols are genuinely complex.
Stats
Sources & Studies
Dhillo WS. et al., J Neuroendocrinol, 2008