Cathelicidin LL-37 · hCAP18
Human antimicrobial peptide — infection, wound healing, immune modulation.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~3–6 hours
ROUTE
Topical, intranasal, or SubQ injection
SCHEDULE
Daily
In Plain English
Human antimicrobial peptide — infection, wound healing, immune modulation.
Status & Legality
What do these mean?ROUTE
?Administration via topical, intranasal, or subq injection.
Wound healing
Antimicrobial
Immune modulation
Biofilm disruption
LL-37 is the only known human member of the cathelicidin family of antimicrobial peptides. It's produced naturally in response to infection and injury. LL-37 disrupts bacterial membranes, modulates immune responses, promotes wound closure, and has shown activity against antibiotic-resistant bacteria including MRSA.
Injection site inflammation
Possible skin irritation (topical)
Flu-like symptoms at high doses
Injecting SubQ for wound healing instead of applying topically at the wound site — topical at the target tissue is far more effective
Using it prophylactically long-term without cycling — reserve for acute infections or active wounds
Combining with high-dose antibiotics without monitoring — additive antimicrobial effects can alter the wound microbiome
Antibiotics — additive antimicrobial effect; generally synergistic for wound care and biofilm disruption
Anti-inflammatory drugs — LL-37 has its own immune-modulatory effects that may compound anti-inflammatory therapy
No established major adverse drug interactions in current literature
LL-37 is the most underutilized antimicrobial peptide in the research space. For chronic wounds or biofilm infections that haven't responded to antibiotics, topical LL-37 is worth exploring. The intranasal route for sinus and respiratory applications is promising but still early-stage in terms of evidence.
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Stats
Sources & Studies
Zanetti M., Biochim Biophys Acta, 2004