AT-1001 · INN-202
Tight junction peptide — leaky gut and celiac.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~4–6 hours
ROUTE
Oral
SCHEDULE
3× daily with meals
In Plain English
Tight junction peptide — leaky gut and celiac.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
OralAdministration via oral.
Leaky gut
Celiac disease
Intestinal permeability
Autoimmune gut conditions
Larazotide acetate is an 8-amino acid peptide that regulates tight junction assembly in intestinal epithelial cells. It works by blocking zonulin-mediated tight junction opening — the primary mechanism behind leaky gut syndrome. Phase II/III clinical trials for celiac disease showed significant reduction in intestinal permeability and symptom scores.
Headache
Nausea (mild)
Generally very well tolerated in trials
Taking without meals — Larazotide works at the tight junction level during active food transit; meal-timing is part of the mechanism
Stopping when symptoms improve — leaky gut restoration requires sustained treatment (8–12 weeks minimum)
Treating as a standalone — it seals junctions but doesn't repair damaged tissue; pair with BPC-157 for repair
GLP-2 analogs (Teduglutide) — additive intestinal repair at the mucosal level; generally beneficial combination
Probiotics — synergistic for gut barrier improvement; commonly combined in gut restoration protocols
No known significant adverse drug interactions in current literature
Larazotide is the only peptide that directly addresses tight junction dysfunction — the actual mechanism of leaky gut. It seals the gates that zonulin pries open. Most powerful when combined with BPC-157 (tissue repair) and a dietary protocol that removes the triggers driving zonulin production in the first place.
Stats
Sources & Studies
Kelly CP. et al., Gastroenterology, 2013