AT-1001 · INN-202
Tight junction peptide — leaky gut and celiac.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~4–6 hours
ROUTE
Oral
SCHEDULE
3× daily with meals
In Plain English
Tight junction peptide — leaky gut and celiac.
Status & Legality
What do these mean?Leaky gut
Celiac disease
Intestinal permeability
Autoimmune gut conditions
Larazotide acetate is an 8-amino acid peptide that regulates tight junction assembly in intestinal epithelial cells. It works by blocking zonulin-mediated tight junction opening — the primary mechanism behind leaky gut syndrome. Phase II/III clinical trials for celiac disease showed significant reduction in intestinal permeability and symptom scores.
Headache
Nausea (mild)
Generally very well tolerated in trials
Taking without meals — Larazotide works at the tight junction level during active food transit; meal-timing is part of the mechanism
Stopping when symptoms improve — leaky gut restoration requires sustained treatment (8–12 weeks minimum)
Treating as a standalone — it seals junctions but doesn't repair damaged tissue; pair with BPC-157 for repair
GLP-2 analogs (Teduglutide) — additive intestinal repair at the mucosal level; generally beneficial combination
Probiotics — synergistic for gut barrier improvement; commonly combined in gut restoration protocols
No known significant adverse drug interactions in current literature
Larazotide is the only peptide that directly addresses tight junction dysfunction — the actual mechanism of leaky gut. It seals the gates that zonulin pries open. Most powerful when combined with BPC-157 (tissue repair) and a dietary protocol that removes the triggers driving zonulin production in the first place.
BPC-157
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Stats
Sources & Studies
Kelly CP. et al., Gastroenterology, 2013