Magnesium Bisglycinate · Chelated Magnesium · Mg Glycinate
The most tolerated magnesium form — critical electrolyte depleted on GLP-1 protocols.
FDA
Approved
WADA
Not Listed
HALF-LIFE
N/A (mineral)
ROUTE
Oral
SCHEDULE
Daily, pre-sleep
In Plain English
The most tolerated magnesium form — critical electrolyte depleted on GLP-1 protocols.
Status & Legality
What do these mean?Electrolyte repletion
Sleep quality
Muscle relaxation
GLP-1 adjunct
Magnesium is a cofactor for 300+ enzymatic reactions and roughly 50% of people are deficient at baseline. GLP-1 users are at especially high risk: reduced appetite, GI side effects, and rapid weight loss all deplete magnesium. Glycinate form — bound to glycine — provides superior absorption and gut tolerance versus oxide or citrate. It also crosses the blood-brain barrier, contributing to anxiolytic and sleep-quality effects.
Loose stool at high doses (less common with glycinate vs. citrate)
Drowsiness — use at night intentionally
Hypotension in rare cases at high doses
Generally very well tolerated
Using magnesium oxide (the most common and cheapest form) — only ~4% absorption vs 80%+ for glycinate; you're essentially taking an inert capsule
Taking it in the morning when pre-sleep timing maximizes both relaxation and sleep quality benefits from the glycine component
Starting at 400 mg immediately when some people experience loose stool — begin at 200 mg and increase over 1–2 weeks
Antibiotics (tetracyclines, fluoroquinolones) — magnesium chelates with these antibiotics, reducing their absorption; separate by 2 hours
Bisphosphonates (osteoporosis medications) — similar chelation concern; separate by 2+ hours
Calcium supplements — compete for absorption at high doses; take calcium in the morning, magnesium at night
Magnesium is deficient in roughly 50% of people at baseline — and GLP-1 protocols make this dramatically worse through reduced food intake and GI losses. Glycinate form is the non-negotiable choice: well-absorbed and well-tolerated. The pre-sleep timing is intentional — glycine itself has sleep-promoting effects that compound with magnesium's muscle relaxation.
DSIP
The original sleep peptide — delta wave induction and stress reduction.
SEMAGLUTIDE
FDA-approved GLP-1 agonist — weight loss and blood sugar control.
EPITHALON
Telomere extension peptide — the longevity compound.
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Stats
Sources & Studies
Tarleton EK. et al., PLoS One, 2017