Ala-Glu-Asp · EDG tripeptide
Pineal gland peptide — neuroprotection and biological clock regulation.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
Unknown
ROUTE
SubQ injection or intranasal
SCHEDULE
Daily (10-day cycle)
In Plain English
Pineal gland peptide — neuroprotection and biological clock regulation.
Status & Legality
NATTY?
No Test ExistsNo established test exists for this compound.
FDA
Research OnlyFor research purposes only. Not FDA approved.
WADA
Not ListedNot currently on WADA prohibited list.
COMPOUNDING
Not from pharmaciesNot available from licensed compounding pharmacies.
PRESCRIBED
Not prescribedNot prescribed in conventional medicine.
ROUTE
SubQ injection or intranasalAdministration via subq injection or intranasal.
Neuroprotection
Circadian rhythm
Cognitive aging
Retinal health
Pinealon is a tripeptide (EDG) derived from the pineal gland that regulates biological clock function and provides neuroprotection. Russian research shows it improves circadian rhythms, protects against age-related neurodegeneration, enhances visual acuity, and reduces all-cause mortality when used in longevity protocols.
Mild headache (rare)
Vivid dreams
Generally very well tolerated
Not combining with Epithalon — Pinealon + Epithalon is the standard Russian neuroprotection protocol; running solo misses the complementary mechanisms
Expecting cognitive improvements within days — effects are cumulative over the 10-day cycle and across months of consistent cycling
Injecting IM instead of SubQ or intranasal — the preferred routes for Pinealon are SubQ or intranasal
Melatonin — synergistic for circadian regulation and sleep quality optimization
SSRIs — may interact via serotonin pathway modulation given Pinealon's circadian involvement
No known significant adverse drug interactions
Pinealon is the most overlooked compound in the Russian longevity peptide set. The circadian regulation and retinal health effects are distinctive — no other peptide in the index targets biological clock function this directly. Best used as part of the Epithalon + Thymalin cycle rather than standalone.
Stats
Sources & Studies
Pinealon increases cell viability and reduces caspase-3 activity in photoreceptors and retinal pigment epithelium
Khavinson VKh. et al., Neuroendocrinol Lett, 2012