GVS-111 · N-phenylacetyl-L-prolylglycine ethyl ester
Dipeptide-derived nootropic — memory, focus, and neuroprotection.
FDA
Research Only
WADA
Not Listed
HALF-LIFE
~15–30 minutes
ROUTE
Oral or sublingual
SCHEDULE
Daily
In Plain English
Dipeptide-derived nootropic — memory, focus, and neuroprotection.
Status & Legality
What do these mean?Memory
Focus
Neuroprotection
Anxiety reduction
Noopept is a dipeptide-derived smart drug (technically a prodrug for cycloprolylglycine) that provides racetam-like cognitive enhancement at much lower doses. It increases BDNF and NGF expression, improves memory consolidation, and has neuroprotective properties. One of the most accessible nootropic peptides.
Headaches (without choline)
Brain fog initially (rare)
Irritability at high doses
Skipping choline supplementation — Noopept's cognitive effects are blunted and headaches develop without adequate choline; 300–500 mg choline bitartrate is non-negotiable
Dosing more than twice daily — no additional benefit above 2 doses; only headache and irritability risk
Expecting stimulant-like energy — Noopept enhances memory consolidation and learning, not raw energy or focus; the effect is subtler
Cholinergic compounds (alpha-GPC, choline) — additive; required alongside Noopept for headache prevention and full effect
Racetams (piracetam, aniracetam) — same mechanism; combining is largely redundant; choose one
Stimulants — may mask overstimulation warning signs; use caution
Noopept is the most accessible nootropic peptide — oral, inexpensive, and well-understood. The choline requirement is real and absolute: take 300–500 mg choline bitartrate with it or expect headaches within a week. Memory consolidation effects are strongest with consistent daily use over 4–6 weeks rather than as-needed dosing.
SEMAX
Neuroprotective ACTH analog — focus, memory, and BDNF.
SELANK
Anti-anxiety nootropic — calm focus without sedation.
DIHEXA
7× more potent than BDNF — the strongest nootropic peptide.
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Stats
Sources & Studies
Ostrovskaya RU. et al., Bull Exp Biol Med, 2008