Egrifta · TH9507
FDA-approved GHRH analog — visceral fat reduction.
FDA
Approved
WADA
Banned
HALF-LIFE
~26 minutes
ROUTE
SubQ injection
SCHEDULE
Daily
In Plain English
FDA-approved GHRH analog — visceral fat reduction.
Status & Legality
What do these mean?Visceral fat reduction
HIV lipodystrophy
GH deficiency
Cognitive function
Tesamorelin is the only FDA-approved GHRH analog, approved specifically for HIV-associated lipodystrophy (excess visceral fat). It stimulates the pituitary to release GH, leading to visceral adipose tissue reduction. Research also shows improvement in cognitive performance in older adults and GH-deficient patients.
Joint/muscle pain
Injection site reactions
Fluid retention
Nausea
Glucose intolerance at high doses
Skipping IGF-1 monitoring — elevated IGF-1 is the key efficacy marker and the primary safety indicator for GH axis protocols
Expecting visceral fat results without dietary changes — tesamorelin reduces fat, but doesn't override a poor diet
Not monitoring glucose — tesamorelin can cause glucose intolerance at the full 2 mg dose, especially in those with metabolic risk
Glucocorticoids — significantly blunt the GHRH response; avoid combining
Insulin and diabetes medications — glucose management requires monitoring during GH elevation
Thyroid hormones — adequate thyroid function is needed for the full GH axis response; test thyroid before starting
Tesamorelin is the most evidence-backed GHRH for visceral fat reduction — the only FDA-approved GHRH analog in existence. If reducing visceral fat is the primary goal, 2 mg/day for 6+ months with IGF-1 monitoring is the gold standard protocol. Significantly more targeted than generalist GH secretagogue approaches.
IPAMORELIN
Cleanest GH secretagogue — minimal cortisol, strong pulse.
AOD-9604
HGH fragment for targeted fat burning — no anabolic effects.
CJC-1295 (NO DAC)
Short-acting GHRH analog — clean GH pulses.
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Stats
Sources & Studies
Falutz J. et al., N Engl J Med, 2010